This study examined global resting‐state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band‐dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.

中文翻译：

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有和没有听力损失的耳鸣神经振荡的全局静息状态功能连接。

这项研究检查了慢性耳鸣、听力正常和受损的个体神经振荡的整体静息状态功能连接。我们测试了不同的神经振荡网络参与耳鸣和听力损失的假设。在有和没有听力损失的两个耳鸣组中，我们确定了多个依赖于频带的区域，这些区域的全局功能连接性增加和减少。我们还发现，通过耳鸣功能指数测定的耳鸣严重程度的听觉域与听觉和非听觉区域的全局功能连接相关。这些发现提供了候选生物标志物，以针对有无听力损失的耳鸣进行靶向和监测治疗。