Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.,Human Brain Mapping

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Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-04-03 , DOI: 10.1002/hbm.24987
Monica N Toba _{1,

2,

3,

4} , Melissa Zavaglia _{2,

5} , Caroline Malherbe _{2,

6} , Tristan Moreau ₁ , Federica Rastelli _{1,

3} , Anna Kaglik _{1,

3} , Romain Valabrègue ₇ , Pascale Pradat-Diehl _{3,

8} , Claus C Hilgetag _{2,

9} , Antoni Valero-Cabré _{1,

3,

10}

Affiliation

Cerebral Dynamics, Plasticity and Rehabilitation Team, Frontlab, Paris Brain Institute, ICM, Sorbonne Universités, UPMC Paris 06, Inserm UMR S 1127, CNRS UMR 7225, F-75013, & IHU-A-ICM, Paris, France.
Institute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
AP-HP, HxU Pitié-Salpêtrière-Charles-Foix, service de Médecine Physique et de Réadaptation & PHRC Régional NEGLECT, Paris, France.
Laboratory of Functional Neurosciences (EA 4559), University of Picardie Jules Verne, Amiens, France.
Jacobs University, Focus Area Health, Bremen, Germany.
Department of Neurology, Head and Neuro Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Centre for NeuroImaging Research-CENIR, Paris Brain Institute, ICM, Sorbonne Universités, Inserm UMR S 1127, CNRS UMR 7225, F-75013, Paris, France.
GRC-UPMC n° 18-Handicap cognitif et réadaptation, Paris, France.
Department of Health Sciences, Boston University, 635 Commonwealth Ave., Boston, Massachusetts, 02215, USA.
Laboratory for Cerebral Dynamics, Plasticity & Rehabilitation, Boston University School of Medicine, Boston, Massachusetts, 02118, USA.

White matter bundles linking gray matter nodes are key anatomical players to fully characterize associations between brain systems and cognitive functions. Here we used a multivariate lesion inference approach grounded in coalitional game theory (multiperturbation Shapley value analysis, MSA) to infer causal contributions of white matter bundles to visuospatial orienting of attention. Our work is based on the characterization of the lesion patterns of 25 right hemisphere stroke patients and the causal analysis of their impact on three neuropsychological tasks: line bisection , letter cancellation , and bells cancellation . We report that, out of the 11 white matter bundles included in our MSA coalitions, the optic radiations, the inferior fronto‐occipital fasciculus and the anterior cingulum were the only tracts to display task‐invariant contributions (positive, positive, and negative, respectively) to the tasks. We also report task‐dependent influences for the branches of the superior longitudinal fasciculus and the posterior cingulum. By extending prior findings to white matter tracts linking key gray matter nodes, we further characterize from a network perspective the anatomical basis of visual and attentional orienting processes. The knowledge about interactions patterns mediated by white matter tracts linking cortical nodes of attention orienting networks, consolidated by further studies, may help develop and customize brain stimulation approaches for the rehabilitation of visuospatial neglect.

中文翻译：

白质对偏盲脑卒中患者视觉空间注意力贡献的博弈理论映射。

连接灰质节点的白质束是充分表征大脑系统和认知功能之间关联的关键解剖学参与者。在这里，我们使用基于联合博弈论（多扰动 Shapley 值分析，MSA）的多元病变推断方法来推断白质束对注意力的视觉空间定向的因果贡献。我们的工作基于对 25 名右半球中风患者的病变模式的表征以及它们对三项神经心理学任务的影响的因果分析：线二等分、字母取消和铃声取消。. 我们报告说，在我们的 MSA 联盟中包含的 11 个白质束中，视辐射、下额枕叶束和前扣带是唯一显示任务不变贡献的束（分别为正、正和负） ) 的任务。我们还报告了对上纵束和后扣带的分支的任务依赖性影响。通过将先前的发现扩展到连接关键灰质节点的白质束，我们从网络的角度进一步描述了视觉和注意力定向过程的解剖学基础。由连接注意力导向网络的皮质节点的白质束介导的交互模式的知识，通过进一步的研究得到巩固，

更新日期：2020-04-03

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