The “adenosine hypothesis of SUDEP” (sudden unexpected death in epilepsy) predicts that a seizure‐induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. Our aim was to correlate the distribution of ADK and adenosine A2A and A1 receptors (A2AR and A1R) in surgical tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE/HS) with SUDEP risk factors.

中文翻译：

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颞叶癫痫和海马硬化中的腺苷激酶和腺苷受体 A1 R 和 A2A R 以及与 SUDEP 危险因素的相关性

“SUDEP 的腺苷假说”（癫痫中的突然意外死亡）预测，癫痫发作引起的腺苷激增与代谢清除受损相结合可导致致命的呼吸暂停或心脏骤停。手术癫痫患者会发生腺苷受体密度和腺苷激酶 (ADK) 的变化。我们的目的是将 ADK 和腺苷 A2A 和 A1 受体（A2AR 和 A1R）在颞叶癫痫和海马硬化 (TLE/HS) 患者手术组织中的分布与 SUDEP 危险因素相关联。