New insight into the role of substance P/neurokinin-1 receptor system in breast cancer progression and its crosstalk with microRNAs.,Clinical Genetics

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New insight into the role of substance P/neurokinin-1 receptor system in breast cancer progression and its crosstalk with microRNAs.
Clinical Genetics ( IF 2.9 ) Pub Date : 2020-04-08 , DOI: 10.1111/cge.13750
Safieh Ebrahimi _{1,

2} , Hosein Javid _{1,

2} , Amin Alaei _{1,

2} , Seyed Isaac Hashemy _{1,

3}

Affiliation

The neuropeptide substance P (SP) triggers a variety of tumor‐promoting signaling pathways through the activation of neurokinin‐1receptor (NK1R), a class of neurokinin G protein‐coupled receptors superfamily. Recent researches in our and other laboratories have shown the overexpression of both SP and NK1R in breast cancer (BC) patients. SP/NK1R signaling is strongly implicated in the pathogenesis of BC through affecting cell proliferation, migration, metastasis, angiogenesis, and resistance. Therefore, SP/NK1R signaling responses must be rigorously regulated; otherwise, they would contribute to a more aggressive BC phenotype. Recently, microRNAs (miRNAs) as a specific class of epigenetic regulators have been shown to regulate NK1R and thus, controlling SP/NK1R signaling responses in BC. This review summarizes the current knowledge of the role of SP/NK1R signaling and its therapeutic potentials in BC. We also provide an overview regarding the effects of miRNA‐mediated NK1R regulatory mechanisms in controlling BC tumorigenesis to gain a clearer view and thus better management of cancer.

中文翻译：

P物质/神经激肽-1受体系统在乳腺癌进展中的作用及其与microRNA的串扰的新见解。

神经肽物质P（SP）通过激活神经激肽1受体（NK1R）（神经激肽G蛋白偶联受体的一个超家族）触发多种促肿瘤信号通路。我们和其他实验室的最新研究表明，乳腺癌（BC）患者中SP和NK1R均过表达。SP / NK1R信号传导通过影响细胞增殖，迁移，转移，血管生成和耐药性而与BC的发病机理密切相关。因此，必须严格调节SP / NK1R信号响应。否则，它们将有助于更具攻击性的BC表型。近来，已显示出作为特定类型的表观遗传调节剂的microRNA（miRNA）可调节NK1R，从而控制BC中的SP / NK1R信号传导响应。这篇综述总结了SP / NK1R信号传导的作用及其在BC中的治疗潜力的当前知识。我们还提供了有关miRNA介导的NK1R调节机制在控制BC肿瘤发生中的作用的概述，以便获得更清晰的视野，从而更好地管理癌症。

更新日期：2020-04-08

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