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The Mechanical Role of Microtubules in Tissue Remodeling
BioEssays ( IF 3.2 ) Pub Date : 2020-04-06 , DOI: 10.1002/bies.201900244 Maja Matis 1, 2
BioEssays ( IF 3.2 ) Pub Date : 2020-04-06 , DOI: 10.1002/bies.201900244 Maja Matis 1, 2
Affiliation
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During morphogenesis, tissues undergo extensive remodeling to get their final shape. Such precise sculpting requires the application of forces generated within cells by the cytoskeleton and transmission of these forces through adhesion molecules within and between neighboring cells. Within individual cells, microtubules together with actomyosin filaments and intermediate filaments form the composite cytoskeleton that controls cell mechanics during tissue rearrangements. While studies have established the importance of actin‐based mechanical forces that are coupled via intercellular junctions, relatively little is known about the contribution of other cytoskeletal components such as microtubules to cell mechanics during morphogenesis. In this review the focus is on recent findings, highlighting the direct mechanical role of microtubules beyond its well‐established role in trafficking and signaling during tissue formation.
中文翻译：
微管在组织重塑中的机械作用
在形态发生过程中，组织经过广泛的重塑以获得最终形状。这种精确的雕刻需要应用细胞骨架在细胞内产生的力，并通过相邻细胞内和相邻细胞之间的粘附分子传递这些力。在单个细胞内，微管与肌动球蛋白丝和中间丝一起形成复合细胞骨架，在组织重排过程中控制细胞力学。虽然研究已经确定了通过细胞间连接耦合的基于肌动蛋白的机械力的重要性，但对其他细胞骨架成分（如微管）在形态发生过程中对细胞力学的贡献知之甚少。在这篇评论中，重点是最近的发现，
更新日期：2020-04-22
中文翻译：
微管在组织重塑中的机械作用
在形态发生过程中，组织经过广泛的重塑以获得最终形状。这种精确的雕刻需要应用细胞骨架在细胞内产生的力，并通过相邻细胞内和相邻细胞之间的粘附分子传递这些力。在单个细胞内，微管与肌动球蛋白丝和中间丝一起形成复合细胞骨架，在组织重排过程中控制细胞力学。虽然研究已经确定了通过细胞间连接耦合的基于肌动蛋白的机械力的重要性，但对其他细胞骨架成分（如微管）在形态发生过程中对细胞力学的贡献知之甚少。在这篇评论中，重点是最近的发现，
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