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Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?
BioEssays ( IF 3.2 ) Pub Date : 2020-04-01 , DOI: 10.1002/bies.201900231
Srinivasa Subramaniam 1
Affiliation  

Ras homolog enriched in the striatum (Rhes) is a striatal enriched protein that promotes the formation of thin membranous tubes resembling tunneling nanotubes (TNT)-"Rhes tunnels"-that connect neighboring cell and transport cargoes: vesicles and proteins between the neuronal cells. Here the literature on TNT-like structures is reviewed, and the implications of Rhes-mediated TNT, the mechanisms of its formation, and its potential in novel cell-to-cell communication in regulating striatal biology and disease are emphasized. Thought-provoking ideas regarding how Rhes-mediated TNT, if it exists, in vivo, would radically change the way neurons communicate in the brain are discussed.

中文翻译:

瑞斯隧道:大脑纹状体中一种全新的通讯方式?

纹状体中富含的 Ras 同源物 (Rhes) 是一种富含纹状体的蛋白质,可促进类似隧道纳米管 (TNT) 的薄膜管的形成 - “Rhes 隧道” - 连接相邻细胞并在神经元细胞之间运输货物:囊泡和蛋白质。这里回顾了有关 TNT 样结构的文献,并强调了 Rhes 介导的 TNT 的含义、其形成机制及其在调节纹状体生物学和疾病方面的新型细胞间通讯的潜力。讨论了关于 Rhes 介导的 TNT(如果它存在于体内)将如何从根本上改变大脑中神经元通讯方式的发人深省的想法。
更新日期:2020-04-01
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