Protective effects of Avena sativa against oxidative stress-induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model.,Journal of Food Biochemistry

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Protective effects of Avena sativa against oxidative stress-induced kidney damage resulting from an estrogen deficiency in ovariectomized Swiss mice model.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-04-06 , DOI: 10.1111/jfbc.13205
Mabrouka Ltaif ₁ , Manel Gargouri _{1,

2} , Christian Magné ₂ , Abdelfattah El Feki ₁ , Ahlem Soussi ₁

Affiliation

The aim of this study was to evaluate the antioxidant capacity of Avena sativa and to confirm its protective effects on estrogen deficiency in ovariectomized mice (OVX) model. Animals were treated during 21 and 60 days as follows: negative control, positive control treated with oat, ovariectomized, and ovariectomized receiving hormonal or oat treatments, respectively. 21 days post‐surgery, our results showed that ovariectomy increases weight gain and urea level in plasma. After 60 days of treatment, OVX showed a gain in weight, high increases in relative kidney weight, plasmatic creatinine, glutathione peroxidase (GPX) activity, and protein oxidation as shown by elevated protein carbonyl (PCO) and advanced oxidation protein products (AOPP) levels. On the other side, a decrease was detected in catalase activity. Meanwhile, no significant changes in urea level, lipid peroxidation, SOD and GSH activity were detected. Conversely, supplementation with oat reduced weight gain, as well as oxidative stress and oxidation protein in the kidney of OVX mice.

中文翻译：

燕麦燕麦对卵巢切除的瑞士小鼠模型中雌激素缺乏引起的氧化应激诱导的肾脏损害的保护作用。

这项研究的目的是评估燕麦的抗氧化能力并确认其对卵巢切除小鼠（OVX）模型中雌激素缺乏的保护作用。在21天和60天之内，分别对动物进行如下处理：阴性对照，分别用燕麦，去卵巢和去卵巢的荷尔蒙或燕麦处理的阳性对照。手术后21天，我们的结果表明，卵巢切除术可增加体重增加和血浆中尿素水平。经过60天的治疗，OVX表现出体重增加，相对肾脏重量大幅增加，血浆肌酐，谷胱甘肽过氧化物酶（GPX）活性和蛋白质氧化，如蛋白质羰基（PCO）升高和氧化蛋白质产物（AOPP）升高所显示水平。另一方面，检测到过氧化氢酶活性降低。同时，未检测到尿素水平，脂质过氧化，SOD和GSH活性的显着变化。

更新日期：2020-04-06

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