Cirrhosis is a chronic liver disease. The present work aimed to evaluate the regulatory immune effect of curcumin in hepatic cirrhosis induced by carbon tetrachloride (CCl4) injections in experimental rats’ model. Chronic liver fibrosis was induced in experiment animals by recurrent injections of CCl4 for more than 5 weeks. They were divided into five groups: first group was injected with normal saline, second group with CCl4, third, fourth, and fifth groups were injected with CCl4 (intraperitoneal injection) at dose 3 ml/kg, two times weekly for 6 weeks supplemented with the administration of curcumin with concentrations 250, 200, and 150 mg/kg. Immune response was analyzed to different treatments. Interleukin 10 (IL‐10), pro‐inflammatory cytokines TNF‐α, TGF‐1β, and liver histopathological examinations were conducted. The results showed that estimations of IL‐10 concentrations were significantly increased in curcumin groups compared with CCl4 group, whereas TNF‐α and TGF‐1β levels were significantly decreased comparing with CCl4 group. The histopathological examinations for liver tissues showed that curcumin treated groups have almost retained the normal structure of liver tissues. In conclusion, curcumin inhibited hepatic fibrosis and liver fibrogenesis with regulation of the immune system mechanism against invader chemical toxicity.

中文翻译：

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姜黄素对实验性大鼠肝硬化的免疫调节作用。

肝硬化是一种慢性肝病。本研究旨在评估姜黄素在四氯化碳（CCl4）注射引起的大鼠肝炎模型中对肝硬化的调节免疫作用。通过反复注射CCl4 5周以上，在实验动物中诱发了慢性肝纤维化。他们分为五组：第一组注射生理盐水，第二组注射CCl4，第三，第四和第五组注射CCl4（腹膜内注射），剂量为3 ml / kg，每周两次，补充6周施用浓度分别为250、200和150 mg / kg的姜黄素。分析了对不同治疗的免疫反应。进行了白细胞介素10（IL-10），促炎细胞因子TNF-α，TGF-1β和肝组织病理学检查。结果表明，姜黄素组的IL-10浓度估计值与CCl4组相比显着增加，而TNF-α和TGF-1β的水平与CCl4组相比显着降低。肝组织的组织病理学检查显示姜黄素治疗组几乎保留了肝组织的正常结构。总之，姜黄素通过调节抵抗入侵者化学毒性的免疫系统机制来抑制肝纤维化和肝纤维化。肝组织的组织病理学检查显示姜黄素治疗组几乎保留了肝组织的正常结构。总之，姜黄素通过调节抵抗入侵者化学毒性的免疫系统机制来抑制肝纤维化和肝纤维化。肝组织的组织病理学检查显示姜黄素治疗组几乎保留了肝组织的正常结构。总之，姜黄素通过调节抵抗入侵者化学毒性的免疫系统机制来抑制肝纤维化和肝纤维化。