Neuroprotective effect from Salvia hispanica peptide fractions on pro-inflammatory modulation of HMC3 microglial cells.,Journal of Food Biochemistry

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Neuroprotective effect from Salvia hispanica peptide fractions on pro-inflammatory modulation of HMC3 microglial cells.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-03-24 , DOI: 10.1111/jfbc.13207
Edwin E Martínez Leo ₁ , Maira R Segura Campos ₁

Affiliation

Neuroinflammation plays a critical role in the neurodegenerative disease's development, where microglia's act an important role in the mechanisms of response to neuronal damage. In the present research, the neuroprotective effect from Salvia hispanica peptide fractions on the proinflammatory modulation on HMC3 microglial cells was evaluated. From the enzymatic hydrolysis of a protein‐rich fraction from S. hispanica seeds, three peptide fractions (<1, 1–3 and 3–5 kDa) were obtained, from which its neuroprotective and anti‐inflammatory effect was determined on the production of proinflammatory mediators on HMC3 cells. The F1–3 kDa exhibited the greatest protective effect (79.04%), associated with the decrease in ROS cell production (51.3 ± 2.3%). Likewise, F1–3 kDa at 50 µg/ml, presented the highest reduction percentages of NO (33.1 ± 2.30%), TNFα (26.4 ± 1.1%) and IL6 (17.36 ± 1.6%). F1–3 kDa exhibited a neuroprotective effect in HMC3 cells associated with its antioxidant and anti‐inflammatory effect.

中文翻译：

丹参丹参肽级分对HMC3小胶质细胞促炎性调节的神经保护作用。

神经炎症在神经退行性疾病的发展中起关键作用，其中小胶质细胞在对神经元损伤的反应机制中起重要作用。在本研究中，评价了丹参丹参肽级分对HMC3小胶质细胞促炎性调节的神经保护作用。来自西班牙链球菌的富含蛋白质的部分的酶促水解在种子中，获得了三个肽级分（<1、1-3和3-5 kDa），并据此确定了其对HMC3细胞促炎性介质产生的神经保护作用和抗炎作用。F1–3 kDa表现出最大的保护作用（79.04％），与ROS细胞产生的减少有关（51.3±2.3％）。同样，F1–3 kDa（50 µg / ml）表现出最高的NO（33.1±2.30％），TNFα（26.4±1.1％）和IL6（17.36±1.6％）减少百分比。F1-3kDa对HMC3细胞具有抗氧化和抗炎作用，具有神经保护作用。

更新日期：2020-03-24

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