This study reported the fabrication and characterization of an electrospun wound dressing composed of polyvinyl alcohol (PVA), nanochitosan (NC), and Artemisia ciniformis extract (AE). NC and AE wt% were defined as process parameters, and their effects on the diameter, mechanical properties, and cell attachment of the fibers were investigated using the Design Expert 7.0 software. The software provided quadratic equations, which were investigated statistically and graphically, confirmed that with the increase in the NC portion in the samples, the mechanical strength and fiber diameter increased. The increase is probably due to the proper dispersion of nanoparticle into a PVA matrix and the increased viscosity of the solution; however, cell viability showed an increasing/decreasing trend. The presence of AE lowered the mechanical properties of the samples while positively affecting cell viability. Furthermore, the samples had significant antibacterial properties against Escherichia coli as Gram‐negative bacteria and Staphylococcus aureus as Gram‐positive one, a notable property for wound dressings. Overall, our findings showed that PVA/NC/AE has an excellent potential for use in biomedical fields, particularly as a wound dressing.

中文翻译：

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由聚乙烯醇/纳米壳聚糖/青蒿提取物组成的伤口敷料的制备和表征：RSM研究

这项研究报告了由聚乙烯醇（PVA），纳米壳聚糖（NC）和青蒿组成的电纺伤口敷料的制备和表征提取物（AE）。将NC和AE重量％定义为工艺参数，并使用Design Expert 7.0软件研究它们对纤维直径，机械性能和细胞附着的影响。该软件提供了二次方程，通过统计学和图形方法进行了研究，证实了随着样品中NC含量的增加，机械强度和纤维直径也随之增加。这种增加可能是由于纳米颗粒适当分散在PVA基质中以及溶液粘度增加所致。然而，细胞活力显示出增加/减少的趋势。AE的存在降低了样品的机械性能，同时对细胞活力产生了积极影响。此外，样品对大肠杆菌具有显着的抗菌特性革兰氏阴性菌为金黄色葡萄球菌，革兰氏阳性菌为金黄色葡萄球菌，是伤口敷料的显着特性。总体而言，我们的发现表明，PVA / NC / AE在生物医学领域，尤其是在伤口敷料方面具有极好的潜力。