Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. Here, we summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of cancer cells and discuss the possibility of targeting SPAG5 for cancer treatment.

中文翻译：

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SPAG5：新兴的致癌基因。

精子相关抗原5（SPAG5）是一种有丝分裂纺锤体蛋白。最近的研究发现，它在许多人类癌症中都过表达，并起着癌基因的作用。在这里，我们总结了其潜在致癌作用在调节癌细胞的细胞行为中的潜在机制，并讨论了靶向SPAG5进行癌症治疗的可能性。