Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.

急性和慢性应激源是人类精神疾病的常见诱因。实验动物模型及其跨物种翻译给人类对于理解与压力有关的精神疾病的发病机理至关重要。越来越多的证据表明，药理学和非药理学方法均可有效治疗这些疾病。在这里，我们分析人类，啮齿动物和斑马鱼（Danio rerio）数据，以比较与压力相关的精神病理学的非药物治疗和药物治疗的影响。强调在临床和实验模型中减轻日常压力的药理学和环境因素之间可能的协同作用和相互作用，我们认为环境富集作为一种有希望的补充疗法，可用于治疗整个类群的压力诱发的疾病。我们还呼吁广泛使用新型模型生物（例如斑马鱼）来研究此类治疗及其潜在的相互作用。