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Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells.
European Journal of Immunology ( IF 4.5 ) Pub Date : 2020-04-11 , DOI: 10.1002/eji.201948177
Rémi Gayet 1 , Eva Michaud 1 , Francesco Nicoli 2 , Blandine Chanut 1 , Mireille Paul 3 , Nicolas Rochereau 1 , Christophe Guillon 4 , Zhiguo He 5 , Laura Papagno 2 , Gilles Bioley 5 , Blaise Corthesy 6 , Stéphane Paul 1
Affiliation  

Human IgA could be from different isotypes (IgA1/IgA2) and/or isoforms (monomeric, dimeric, or secretory). Monomeric IgA mainly IgA1 are considered as an anti‐inflammatory isotype whereas dimeric/secretory IgA have clearly dual pro‐ and anti‐inflammatory effects. Here, we show that IgA isotypes and isoforms display different binding abilities to FcαRI, Dectin‐1, DC‐SIGN, and CD71 on monocyte‐derived dendritic cells (moDC). We describe that IgA regulate the expression of their own receptors and trigger modulation of moDC maturation. We also demonstrate that dimeric IgA2 and IgA1 induce different inflammatory responses leading to cytotoxic CD8+ T cells activation. moDC stimulation by dimeric IgA2 was followed by a strong pro‐inflammatory effect. Our study highlights differences regarding IgA isotypes and isoforms in the context of DC conditioning. Further investigations are needed on the activation of adaptive immunity by IgA in the context of microbiota/IgA complexes during antibody‐mediated immune selection.

中文翻译:

IgA亚型对其激活树突状细胞和引发T细胞的能力的影响。

人IgA可能来自不同的同种型(IgA1 / IgA2)和/或同种型(单体,二聚体或分泌型)。单体IgA主要是IgA1被认为是抗炎同种型,而二聚体/分泌型IgA显然具有促炎和抗炎双重作用。在这里,我们显示了IgA同种型和同种型对单核细胞来源的树突状细胞(moDC)上的FcαRI,Dectin-1,DC-SIGN和CD71具有不同的结合能力。我们描述了IgA调节其自身受体的表达并触发对moDC成熟的调节。我们还证明了二聚体IgA2和IgA1会诱导不同的炎症反应,从而导致细胞毒性CD8 +T细胞活化。二聚体IgA2刺激moDC,然后产生强烈的促炎作用。我们的研究突出了DC条件下IgA同种型和同种型的差异。在抗体介导的免疫选择过程中,在微生物群/ IgA复合体的背景下,需要进一步研究IgA激活适应性免疫。
更新日期:2020-04-11
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