Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle,Phytochemistry

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Terpenylated coumarins from the root bark of Ailanthus altissima (Mill.) Swingle
Phytochemistry ( IF 3.2 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.phytochem.2020.112361
Zhi-Yang Yan ₁ , Tian-Ming Lv ₁ , Yu-Xi Wang ₁ , Shao-Chun Shi ₁ , Jing-Jie Chen ₁ , Bin-Lin ₂ , Qing-Bo Liu ₁ , Xiao-Xiao Huang ₁ , Shao-Jiang Song ₁

Affiliation

Seven undescribed terpenylated coumarins, named altissimacoumarin I-O, together with seven known compounds, altissimacoumarin C, altissimacoumarin E, altissimacoumarin G, altissimacoumarin H, puberulin, 7-(3-Methyl-2-butenyloxy)-6-methoxycoumarin and artelin were isolated from the root bark of Ailanthus altissima (Mill.) Swingle. Their structures were elucidated by comprehensive spectra data analysis, NMR calculation, DP4+ analysis and ACD/Structure Elucidator software simulation. The absolute configurations of altissimacoumarins K, L, M and N were determined by modified Mosher's method. All isolates were tested for their cytotoxic effect against two hepatoma carcinoma cell lines (HepG2, Hep3B). Altissimacoumarin C exhibited moderate cytotoxic effect against Hep3B cells, with IC50 of 45.21 μM.

中文翻译：

臭椿根皮中的萜烯化香豆素 (Mill.) Swingle

七种未描述的萜烯化香豆素，命名为 altissimacoumarin IO，连同七种已知化合物，altissimacoumarin C、altissimacoumarin E、altissimacoumarin G、altissimacoumarin H、puberulin、7-(3-Methyl-2-butenyloxy)-6-theeloxyincoumarin臭椿根皮 (Mill.) Swingle。通过综合光谱数据分析、核磁共振计算、DP4+分析和ACD/Structure Elucidator软件模拟阐明了它们的结构。altissimacoumarins K、L、M 和 N 的绝对构型通过改进的 Mosher 方法确定。测试了所有分离株对两种肝癌细胞系（HepG2、Hep3B）的细胞毒性作用。Altissimacoumarin C 对 Hep3B 细胞表现出中等的细胞毒作用，IC50 为 45.21 μM。

更新日期：2020-07-01

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