Interferon regulatory factors (IRFs) are a family of central transcriptional regulators that produce type I interferon and regulate innate and adaptive immune responses. Interferon regulatory factor 8 (IRF8) exists mainly in hematopoietic cells and is essential for the development of several myeloid lineages, including monocytes/macrophages and dendritic cells. In recent years, an increasing number of studies have focused on the roles of IRF8 in the differentiation of myeloid pedigree and MDSC aggregation in diseases such as tumors. In this review, we provide a comprehensive overview of the roles of IRF8 in the regulation of myeloid cell development, with particular reference to multiple disease conditions. Clarifying the various functions of IRF8 may suggest targets for therapeutic interventions.

干扰素调节因子 (IRF) 是一个中枢转录调节因子家族，可产生 I​​ 型干扰素并调节先天性和适应性免疫反应。干扰素调节因子 8 (IRF8) 主要存在于造血细胞中，对几种骨髓谱系的发育至关重要，包括单核细胞/巨噬细胞和树突细胞。近年来，越来越多的研究集中在 IRF8 在髓系谱系分化和 MDSC 聚集在肿瘤等疾病中的作用。在这篇综述中，我们全面概述了 IRF8 在调节骨髓细胞发育中的作用，特别是在多种疾病条件下。阐明 IRF8 的各种功能可能会提示治疗干预的目标。