Our ability to sense mechanical cues from our environment depend on the capacity of molecular sensor capable of converting mechanical energy into biochemical or electrical signals. This process, termed mechanotransduction, relies on the activity of mechanosensitive ion channels (MSCs) that are expressed in most tissues, including cells of the inner and outer ear, sensory and sympathetic neurons, and vascular cells. However, the precise role these channels play in the physiology of the cells and organs, where they are expressed is not completely understood. In this review, we will explore some of the recent findings on the role of MSCs to our sense of mechanical pain.

我们从环境中感应机械提示的能力取决于能够将机械能转换为生化或电信号的分子传感器的能力。此过程称为机械转导，依赖于在大多数组织（包括内耳和外耳细胞，感觉和交感神经元以及血管细胞）中表达的机械敏感离子通道（MSC）的活性。但是，这些通道在表达它们的细胞和器官的生理中所起的确切作用尚不完全清楚。在这篇综述中，我们将探讨有关MSC对我们的机械性疼痛感作用的最新发现。