The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.

中文翻译：

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我们对背角神经元群体的组织及其对皮肤机械性异常性疼痛的贡献的最新进展。

脊髓的背角和脑干中的三叉神经核包含神经元种群，这些种群对于处理感觉信息至关重要。这些区域中的神经元在形态，分子表型和内在特性方面高度异质，因此难以识别功能上不同的细胞群，并难以确定它们如何参与病理生理条件。基于对背角的转录组学和转导学分析，关于神经元种群的分类的共识日益增多。这些方法导致发现了几种分子定义的细胞类型，这些细胞类型涉及皮肤机械性异常性疼痛，这是一种慢性疼痛的高度普遍且难以治疗的症状，其中触摸变得疼痛。