Neuropilin-1 (NRP-1) is known to be related to various types of cancer and is considered a novel tumor marker or therapeutic target. The aim of this study was to identify the clinical implications of NRP-1 expression in terms of prognosis in patients with gastric cancer. A total of 265 patients who underwent radical gastrectomy for the treatment of gastric cancer from 2008 to 2011 were included in this retrospective study. NRP-1 expression of tumors was determined by immunohistochemistry. The patients’ clinicopathological characteristics, operative details, and long-term outcomes were retrospectively analyzed. A total of 181 (68.3%) patients demonstrated expression of NRP-1. No survival difference was observed according to NRP-1 expression in any patient. The patients were divided into the gland formation (GF) and the no gland formation (nGF) types, according to histology. NRP-1 expression rates were 65.6% (84/128) and 70.8% (97/137), respectively. NRP-1 expression was not an independent prognostic factor in the GF group, although patients who expressed NRP-1 had better survival outcomes. In contrast, patients who expressed NRP-1 in the nGF group had worse 5-year survival rates (p = 0.027), and NRP-1 was an independent prognostic factor in a multivariate analysis (hazard ratio, 1.923; 95% confidence interval, 1.041–3.551). NRP-1 expression in patients with nGF type gastric cancer is predictive of a poor prognosis.

中文翻译：

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根据胃癌组织学，neuropilin-1表达与预后之间的关系。

已知Neuropilin-1（NRP-1）与各种类型的癌症有关，被认为是新型的肿瘤标志物或治疗靶标。这项研究的目的是确定NRP-1表达在胃癌患者预后方面的临床意义。这项回顾性研究纳入了2008年至2011年间共265例行胃癌根治术的患者。通过免疫组织化学测定肿瘤的NRP-1表达。回顾性分析患者的临床病理特征，手术细节和长期结果。共有181名（68.3％）患者表现出NRP-1表达。根据NRP-1表达，在任何患者中均未观察到生存差异。根据组织学，将患者分为腺体形成（GF）和无腺体形成（nGF）类型。NRP-1表达率分别为65.6％（84/128）和70.8％（97/137）。尽管表达NRP-1的患者生存期更好，但GF组中NRP-1的表达不是独立的预后因素。相反，在nGF组中表达NRP-1的患者5年生存率较差（p  = 0.027），而NRP-1是多因素分析中的独立预后因素（危险比1.923； 95％置信区间1.041-3.551）。NGF型胃癌患者中NRP-1的表达预示不良预后。