Protein phosphatase 5 (PP5) is a serine/threonine protein phosphatase that regulates many cellular functions including steroid hormone signaling, stress response, proliferation, apoptosis, and DNA repair. PP5 is also a co-chaperone of the heat shock protein 90 molecular chaperone machinery that assists in regulation of cellular signaling pathways essential for cell survival and growth. PP5 plays a significant role in survival and propagation of multiple cancers, which makes it a promising target for cancer therapy. Though there are several naturally occurring PP5 inhibitors, none is specific for PP5. Here, we review the roles of PP5 in cancer progression and survival and discuss the unique features of the PP5 structure that differentiate it from other phosphoprotein phosphatase (PPP) family members and make it an attractive therapeutic target.

中文翻译：

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癌症中辅助伴侣蛋白磷酸酶 5 的结构和功能。


蛋白磷酸酶 5 (PP5) 是一种丝氨酸/苏氨酸蛋白磷酸酶，可调节许多细胞功能，包括类固醇激素信号传导、应激反应、增殖、凋亡和 DNA 修复。 PP5 也是热休克蛋白 90 分子伴侣机制的共伴侣，有助于调节细胞生存和生长所必需的细胞信号传导途径。 PP5 在多种癌症的存活和扩散中发挥着重要作用，这使其成为癌症治疗的有希望的靶点。尽管有几种天然存在的 PP5 抑制剂，但没有一种是专门针对 PP5 的。在这里，我们回顾了 PP5 在癌症进展和生存中的作用，并讨论了 PP5 结构的独特特征，这些特征使其区别于其他磷蛋白磷酸酶 (PPP) 家族成员，并使其成为有吸引力的治疗靶点。