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PET/MRI Radiomics in Rectal Cancer: a Pilot Study on the Correlation Between PET- and MRI-Derived Image Features with a Clinical Interpretation.
Molecular Imaging and Biology ( IF 3.0 ) Pub Date : 2020-04-08 , DOI: 10.1007/s11307-020-01484-x
Barbara Juarez Amorim 1, 2, 3 , Angel Torrado-Carvajal 2, 4 , Shadi A Esfahani 1 , Sara S Marcos 5 , Mark Vangel 1, 2, 6 , Dan Stein 7 , David Groshar 7 , Onofrio A Catalano 1, 2, 8
Affiliation  

Purpose

The aim of this study was to explore possible correlations among different imaging features from 2-deoxy-2-[18F]fluoro-D-Glucose positron emission tomography/magnetic resonance imaging (PET/MRI) in rectal cancer (RC).

Procedures

RC patients who underwent PET/MRI were enrolled. A region of interest (ROI) was drawn around each primary RC on PET/MRI images (PET, pelvic axial T2w, and apparent diffusion coefficient maps (ADC)). Multiple imaging features were assessed, and Pearson’s correlation was used to explore possible correlations among them.

Results

A total of 13 patients were included, mean age 56.1 years old, 6 females. A strong inverse correlation was observed between SUVpeak and ADCmean values, MTV and T2 sphericity, MTV and ADC sphericity, MTV and T2 entropy, and TLG and ADC sphericity. There was also strong direct correlation between PET entropy and ADC sphericity.

Conclusions

In conclusion, several clinically relevant correlations were observed between PET and MRI imaging features. These findings show how the use of both modalities provides complementary information.


中文翻译:

直肠癌中的 PET/MRI 放射组学:一项关于 PET 和 MRI 衍生图像特征与临床解释之间相关性的初步研究。

目的

本研究的目的是探讨直肠癌 (RC) 中2-脱氧-2-[ 18 F] 氟-D-葡萄糖正电子发射断层扫描/磁共振成像 (PET/MRI)不同成像特征之间可能的相关性。

程序

纳入接受 PET/MRI 的 RC 患者。在 PET/MRI 图像(PET、骨盆轴向 T2w 和表观扩散系数图 (ADC))上,围绕每个主要 RC 绘制一个感兴趣区域 (ROI)。评估了多个影像特征,并使用 Pearson 相关性来探索它们之间可能的相关性。

结果

共纳入患者13例,平均年龄56.1岁,女性6例。在 SUVpeak 和 ADCmean 值、MTV 和 T2 球形度、MTV 和 ADC 球形度、MTV 和 T2 熵以及 TLG 和 ADC 球形度之间观察到强烈的负相关。PET 熵和 ADC 球度之间也有很强的直接相关性。

结论

总之,在 PET 和 MRI 成像特征之间观察到了几种临床相关的相关性。这些发现显示了使用这两种方式如何提供补充信息。
更新日期:2020-04-08
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