StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As such, and through the dysregulation of Rho GTPases, this affects adhesion dynamics, actin dynamics, and leads to an increase or a decrease in tumor metastasis depending on the tumor grade and type. Being a key regulatory protein, StarD13 is a potential promising candidate for therapeutic approaches. This paper reviews the key characteristics of this protein and its role in tumor malignancies.

中文翻译：

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StarD13：肿瘤治疗的潜在星标。

StarD13是Rho GTPases的肿瘤抑制因子和GTPase激活蛋白（GAP）。因此，StarD13以p53依赖性和独立方式调节细胞存活途径并诱导细胞凋亡。在肿瘤中，取决于肿瘤类型，StarD13被下调或被完全抑制。这样，通过Rho GTPases的失调，这会影响粘附动力学，肌动蛋白动力学，并导致取决于肿瘤等级和类型的肿瘤转移的增加或减少。作为关键的调节蛋白，StarD13是治疗方法的潜在前途候选者。本文综述了这种蛋白质的关键特征及其在肿瘤恶性肿瘤中的作用。