Circular RNAs (circRNAs) exert pivotal effects on regulating the progression of osteosarcoma (OS). It was found through microarray analysis that circ-0002052 is abnormally expressed in OS, but the role of circ-0002052 in OS remains obscure. The results of this research manifested that relative to that in non-tumor controls, circ-0002052 level was raised in OS tissues. Up-regulated circ-0002052 was associated with advanced stage, tumor size, and metastasis. Additionally, circ-0002052 elevation indicated a low survival rate in OS patients and silencing of circ-0002052 suppressed proliferation, migration, and invasion of OS cells. It was proved that circ-0002052 sponged miR-382 and stimulated STX6 expression, thus activating Wnt/β-catenin. The function of circ-0002052 reduction in OS cells was effectively reversed by miR-382 suppression. To sum up, it can be concluded that circ-0002052, functioning as a sponge for miR-382, enhances the activation of Wnt/β-catenin mediated by STX6 to stimulate the progression of OS, and circ-0002052 may be an underlying treatment target and a biomarker for prognosis of osteosarcoma.

中文翻译：

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环状RNA hsa_circ_0002052通过调节miR-382 / STX6轴促进骨肉瘤。

环状RNA（circRNA）在调节骨肉瘤（OS）的进程中发挥关键作用。通过微阵列分析发现，circ-0002052在OS中异常表达，但是circ-0002052在OS中的作用仍然不清楚。这项研究的结果表明，相对于非肿瘤对照，OS组织中的circ-0002052水平升高。circ-0002052上调与晚期，肿瘤大小和转移有关。另外，circ-0002052升高表明OS患者生存率低，而circ-0002052沉默导致OS细胞增殖，迁移和侵袭受到抑制。事实证明，circ-0002052用海绵擦拭miR-382并刺激STX6表达，从而激活Wnt /β-catenin。miR-382抑制可有效逆转circ-0002052减少OS细胞的功能。综上所述，可以得出结论，circ-0002052充当miR-382的海绵，可增强STX6介导的Wnt /β-catenin的激活，从而刺激OS的进程，而circ-0002052可能是一种潜在的治疗方法靶标和骨肉瘤预后的生物标志物。