The hepatotoxic potential of the methanolic extract of the stems of Tinospora crispa and of its furano-diterpenoid-borapetosides B, C, and F-was investigated in normal and health-compromised mice. Health-compromised condition was established by a single intraperitoneal injection of LPS (6 mg/kg). Two different sets of experiments were conducted to evaluate the hepatotoxic potential. A 21-day study where the mice were dosed with the extract of T. crispa (1 gm/kg b. wt./day) or standardized combination of borapetosides B, C and F (500 mg/kg b. wt.) with or without a single dose of LPS (1 gm/kg b. wt./day). In the acute toxicity study, mice were dosed with borapetosides B, C, and F (500 mg/kg b. wt.). Results showed that the ALT levels were normal and liver histopathology unaltered. No conclusive hepatotoxicity was observed in the methanolic extract or pure compounds tested under the given experimental conditions.

中文翻译：

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在小鼠模型中评估薄蜈蚣及其分离的硼酸硼苷 B、C 和 F 的肝毒性潜力

在正常和健康受损的小鼠中研究了薯蓣茎甲醇提取物及其呋喃二萜类硼烷苷 B、C 和 F-的肝毒性潜力。通过单次腹膜内注射 LPS (6 mg/kg) 建立健康受损状况。进行了两组不同的实验以评估肝毒性潜力。一项为期 21 天的研究，其中给小鼠服用 T.crispa 提取物（1 gm/kg b. wt./day）或硼酸硼苷 B、C 和 F（500 mg/kg b. wt.）的标准化组合与或不服用单剂量 LPS（1 gm/kg b. wt./day）。在急性毒性研究中，给小鼠服用硼烷甙 B、C 和 F（500 毫克/公斤体重）。结果显示ALT水平正常且肝脏组织病理学未改变。