A dual responsive sensor molecule, 2-(4-(2,2′:6′,2″-terpyridin)-4′-yl-phenyl)-N-methyl-3-thiosemicarbazone, has been synthesized and characterized using standard analytical and spectroscopic techniques. The dual binding properties of the sensor molecule were investigated using biologically important inorganic cations (Mn²⁺, Fe²⁺, Ni²⁺, Cu²⁺, Zn²⁺, Pb²⁺ and Hg²⁺) and anions (F¯, Cl¯, Br¯, I¯, HSO₄¯ and H₂PO₄¯). The sensor molecule is equipped with analyte coordinating donor sites displaying charge transfer controlled spectroscopic properties and shows analyte–receptor interactions. Sensing mechanism involving host–guest interactions was confirmed by spectral and cyclic voltammetry techniques. The receptor shows colorimetric signalling in solution for cations such as Mn²⁺, Ni²⁺ and Cu²⁺ as evidenced by instant colour changes even at 2 μL aliquots of manganese and copper cations, and 4 μL aliquot for nickel cation, among the studied cations. Fluoride anion was detected by naked eye even at 2 μL of aliquot, signalled by the development of yellowish brown colour, through hydrogen bonding, deprotonation of N–H fragment and formation of HF₂¯. Thus, the receptor shows dual sensing ability towards selected cations and F¯ anion. Further, paper strip experiments on receptor were also employed for the detection of cations and fluoride anion in solution.

中文翻译：

---

4-功能化的吡啶吡啶衍生物作为生物重要的无机阳离子和氟阴离子的双响应化学传感器

使用标准分析仪合成并表征了双响应传感器分子2-（4-（2,2'：6'，2''-terridridin）-4'-基苯基）-N-甲基-3-硫代半脲和光谱技术。使用生物学上重要的无机阳离子（Mn 2 ⁺，Fe 2 ⁺，Ni 2 ⁺，Cu 2 ⁺，Zn 2 ⁺，Pb ²⁺和Hg ²⁺）和阴离子（F′， Cl，Br，I，HSO ₄和H ₂ PO ₄¯）。传感器分子配备有分析物协调的供体位点，该位点显示出电荷转移控制的光谱特性，并显示了分析物与受体的相互作用。通过光谱和循环伏安技术证实了涉及主客体相互作用的传感机制。该受体在溶液中显示出诸如Mn 2 ⁺，Ni ²⁺和Cu ²⁺等阳离子的比色信号，即使在2μL等分的锰和铜阳离子以及4μL等分的镍阳离子中，其即时颜色变化也证明了这一点。阳离子。甚至在2μL等分试样中，也可以通过肉眼检测到氟阴离子，其信号是通过氢键键合，NH片段的去质子化和HF _2的形成而呈黄褐色的发展。¯.。因此，该受体对选定的阳离子和F'阴离子具有双重感测能力。此外，还对受体进行了纸条实验，以检测溶液中的阳离子和氟离子。