An ion chromatography (IC) method coupled with solid-phase extraction was established for the simultaneous determination of trace organic acids and inorganic anions in sodium carboxymethyl cellulose (CMC). To prevent CMC from contaminating analytical column, a self-packed solid-phase extraction column packed with quaternized adsorbents was applied in sample pretreatment. An IonPac, AS11-HC column was used as the analytical column for separation of glycolate, chloroacetate, chloride, and sulfate with gradient elution of potassium hydroxide at a flow rate of 1.0 mL min −1 . Under the optimized chromatographic conditions, the linearity of the method was satisfactory over a concentration range of 0.5–150.0 mg L −1 with correlation coefficients of 0.9992–0.9999, and the limits of detection varied from 0.05 to 0.1 mg L −1 , based on the signal-to-noise ratio of 3. The proposed method was successfully applied to the analysis of organic acids and inorganic anions in CMC samples. The recoveries ranged from 86.7 to 109.0% with the relative standard deviations (RSDs) over the range of 0.32–3.61%. The method offers a reliable application for the analysis of trace organic acids and inorganic anions in complex anionic cellulose.

中文翻译：

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离子色谱法测定羧甲基纤维素钠中的痕量阴离子

建立了离子色谱法(IC) 与固相萃取相结合的方法，用于同时测定羧甲基纤维素钠(CMC) 中的痕量有机酸和无机阴离子。为防止CMC污染分析柱，样品前处理采用填充季铵化吸附剂的自装固相萃取柱。使用 IonPac、AS11-HC 柱作为分析柱，以 1.0 mL min -1 的流速用氢氧化钾梯度洗脱来分离乙醇酸盐、氯乙酸盐、氯化物和硫酸盐。在优化的色谱条件下，该方法在0.5-150.0 mg L -1 浓度范围内线性良好，相关系数为0.9992-0.9999，检出限为0.05-0.1 mg L -1 ，基于 3 的信噪比。该方法成功应用于 CMC 样品中有机酸和无机阴离子的分析。回收率范围为 86.7% 至 109.0%，相对标准偏差 (RSD) 范围为 0.32% 至 3.61%。该方法为分析复杂阴离子纤维素中的痕量有机酸和无机阴离子提供了可靠的应用。