Background: Ovarian cancer is one of the gynecological malignancies responsible for thousands of deaths in women worldwide. Malignant solid tumors are formed by malignant cells and stroma that influence each other, where different types of cells in the stromal environment can be recruited by malignant cells to promote tumor growth and facilitate metastasis. The chronic inflammatory response is increasingly accepted in its relation to the pathophysiology of the onset and development of tumors, sustained cell proliferation in an environment rich in inflammatory cells, growth factors, activated stroma and DNA damage agents may increase the risk to develop a neoplasm.Methods: A search for the following keywords was performed in the PubMed database; "Ovarian cancer", "stroma", "tumor-associated macrophages", "cancer-associated fibroblasts", "cytokines", "angiogenesis", "epithelial-mesenchymal transition", and "extracellular matrix".Results: The articles identified were published in English between 1971 and 2018. A total of 154 articles were selected for further analysis. Conclusion: We consider ovarian cancer as a heterogeneous disease, not only in the sense that different histological or molecular subtypes may be behind the same clinical result, but also that multiple cell types besides cancer cells, like other non-cellular components, need to be mobilized and coordinated to support tumor survival, growth, invasion and progression.

中文翻译：

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基质在卵巢癌中的作用。

背景：卵巢癌是导致全球成千上万妇女死亡的妇科恶性肿瘤之一。恶性实体瘤是由相互影响的恶性细胞和基质形成的，恶性细胞可以在基质环境中募集基质环境中不同类型的细胞，以促进肿瘤生长和促进转移。慢性炎性反应与肿瘤的发生和发展的病理生理学有关，在炎性细胞，生长因子，活化的基质和DNA损伤剂丰富的环境中持续的细胞增殖可能会增加患上肿瘤的风险，因此日益受到人们的欢迎。方法：在PubMed数据库中搜索以下关键字；“卵巢癌”，“基质”，“肿瘤相关巨噬细胞”，“ 所识别的文章在1971年至2018年之间以英文发表。总共选择了154篇文章进行进一步分析。结论：我们认为卵巢癌是一种异质性疾病，不仅是因为不同的组织学或分子亚型可能是同一临床结果的原因，而且除癌细胞外，还需要像其他非细胞成分一样将多种细胞类型动员并协调以支持肿瘤的存活，生长，侵袭和进展。所识别的文章在1971年至2018年之间以英文发表。总共选择了154篇文章进行进一步分析。结论：我们认为卵巢癌是一种异质性疾病，不仅是因为不同的组织学或分子亚型可能是同一临床结果的原因，而且除癌细胞外，还需要像其他非细胞成分一样将多种细胞类型动员并协调以支持肿瘤的存活，生长，侵袭和进展。