The present study combined the analysis of two transcriptional regulators, uVNTR and dVNTR, in the MAOA gene that is an enzyme responsible for the monoamine degradation and identified genetic interaction between these VNTRs in association with the nicotine dependence. The main impact is that when analyzing different populations in the genetic studies, the functionally meaningful variants should be combined rather than addressing individual elements separately (a mini polygenic risk score for a particular gene/locus). This combination is very rarely analyzed and therefore the study sets an example. Another impact is that we analyzed the genetic variability in the Asian population and therefore our data present a piece of information from underrepresented populations.

中文翻译：

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MAOA基因中两个VNTR之间的遗传相互作用与尼古丁依赖性有关。

本研究结合了MAOA基因中两种转录调节因子uVNTR和dVNTR的分析，该基因是负责单胺降解的酶，并确定了这些VNTR之间的遗传相互作用与尼古丁依赖性。主要的影响是，在基因研究中分析不同的种群时，应该将功能上有意义的变体进行组合，而不是分别处理单个元素（特定基因/基因座的微型多基因风险评分）。这种组合很少被分析，因此该研究为我们树立了榜样。另一个影响是我们分析了亚洲人群的遗传变异性，因此我们的数据提供了来自代表性不足人群的一些信息。