The incidence of HFpEF continues to increase and ∼2/3 of the patient population are post-menopausal women. Unfortunately, most studies focus on the use of male animal models of remodeling. In this study, however, using female rats to set a model of pre-HFpEF, we provide insights to possible mechanisms that contribute to HFpEF development in humans that will lead us to a better understanding of the underlying pathophysiology of HFpEF.

中文翻译：

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HFpEF前模型中炎症在驱动左心室重构中的作用。

HFpEF的发病率持续增加，约2/3的患者是绝经后妇女。不幸的是，大多数研究集中在重塑雄性动物模型上。然而，在这项研究中，使用雌性大鼠建立HFpEF前模型，我们提供了有助于人类HFpEF发育的可能机制的见解，这将使我们更好地了解HFpEF的潜在病理生理。