A prodrome is considered an early set of signs or symptoms indicating the onset of a disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years before our current, classic understanding of “MS symptom onset.” Prodromal periods are well recognized in other neurodegenerative conditions and more recently have been shown in MS. In this Viewpoint, we reflect on the emerging evidence surrounding the MS prodrome, including features that may be common across chronic inflammatory and neurodegenerative diseases. Finally, we discuss the implications for future disease prevention in MS.

中文翻译：

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多发性硬化症前驱症状：新出现的证据、挑战和机遇

前驱症状被认为是一组早期迹象或症状，表明疾病或疾病的发作。在多发性硬化症 (MS) 中，前驱期是我们目前对“MS 症状发作”的经典理解之前的几个月或几年。前驱期在其他神经退行性疾病中得到了很好的认可，最近在 MS 中也得到了证明。在这个观点中，我们反思了围绕 MS 前驱症状的新证据，包括可能在慢性炎症和神经退行性疾病中常见的特征。最后，我们讨论了对 MS 未来疾病预防的影响。