OBJECTIVES Likelihood of clinical events occurring within the same anatomical location in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) was retrospectively investigated. METHODS A total of 236 clinical events in 90 patients with MOGAD from nine referral hospitals were analyzed via logistic regression, and odds ratios (ORs) were calculated. Anatomical lesion location was divided into four groups; optic nerve, spinal cord, cerebral hemisphere, and brainstem/cerebellum. RESULTS At all locations, there was an increased likelihood of a second attack occurring at the same location as the initial event (cerebral hemisphere OR = 22.14, brainstem/cerebellum OR = 18.4, spinal cord OR = 9.1, and optic nerve OR = 7.8). There was an increased likelihood of a third attack occurring at the same location as the initial event in the optic nerve (OR = 14.9), cerebral hemisphere (OR = 11.7), and spinal cord (OR = 6.7). There were positive trends toward a third clinical event occurring at the same location as the first and/or second events if the event was in the optic nerve (OR = 13.5), cerebral hemisphere (OR = 6.9), or spinal cord (OR = 5.7). CONCLUSIONS The current study suggests that clinical relapses of MOGAD during early stage tend to recur at the same anatomical locations in the central nervous system.

中文翻译：

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MOG 抗体相关疾病患者在同一解剖位置的临床事件复发

目的 回顾性研究髓鞘少突胶质细胞糖蛋白抗体相关疾病 (MOGAD) 患者在同一解剖部位发生临床事件的可能性。方法 对来自 9 家转诊医院的 90 名 MOGAD 患者的 236 次临床事件进行逻辑回归分析，并计算比值比（ORs）。解剖病变位置分为四组；视神经、脊髓、大脑半球和脑干/小脑。结果 在所有位置，在与初始事件相同的位置发生第二次发作的可能性增加（大脑半球 OR = 22.14，脑干/小脑 OR = 18.4，脊髓 OR = 9.1，视神经 OR = 7.8） . 视神经 (OR = 14.9)、大脑半球 (OR = 11.7) 和脊髓 (OR = 6.7) 在与初始事件相同的位置发生第三次发作的可能性增加。如果事件发生在视神经 (OR = 13.5)、大脑半球 (OR = 6.9) 或脊髓 (OR = 5.7)。结论 目前的研究表明，早期 MOGAD 的临床复发倾向于在中枢神经系统的相同解剖位置复发。大脑半球（OR = 6.9）或脊髓（OR = 5.7）。结论 目前的研究表明，早期 MOGAD 的临床复发倾向于在中枢神经系统的相同解剖位置复发。大脑半球（OR = 6.9）或脊髓（OR = 5.7）。结论 目前的研究表明，早期 MOGAD 的临床复发倾向于在中枢神经系统的相同解剖位置复发。