Exercise as a subset of physical activity is a cornerstone in the management of multiple sclerosis (MS) based on its pleotropic effects. There is an exponential increase in the quantity of research on exercise in MS, yet a number of barriers associated with study content and quality hamper rapid progress in the field. To address these barriers and accelerate discovery, a new international partnership of MS-related experts in exercise has emerged with the goal of advancing the research agenda. As a first step, the expert panel met in May 2018 and identified the most urgent areas for moving the field forward, and discussed the framework for such a process. This led to identification of five themes, namely “Definitions and terminology,” “Study methodology,” “Reporting and outcomes,” “Adherence to exercise,” and “Mechanisms of action.” Based on the identified themes, five expert groups have been formed, that will further (a) outline the challenges per theme and (b) provide recommendations for moving forward. We aim to involve and collaborate with people with MS/MS organizations (e.g. Multiple Sclerosis International Federation (MSIF) and European Multiple Sclerosis Platform (EMSP)) in all of these five themes. The generation of this thematic framework with multi-expert perspectives can bolster the quality and scope of exercise studies in MS that may ultimately improve the daily lives of people with MS.

中文翻译：

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推动多发性硬化症的运动研究（MoXFo 倡议）：制定研究共识声明

运动作为身体活动的一个子集，是基于其多效性的多发性硬化症 (MS) 管理的基石。MS 运动研究的数量呈指数增长，但与研究内容和质量相关的许多障碍阻碍了该领域的快速进展。为了解决这些障碍并加速发现，一个新的 MS 相关运动专家国际合作伙伴关系已经出现，其目标是推进研究议程。作为第一步，专家小组于 2018 年 5 月召开会议，确定了推动该领域向前发展的最紧迫领域，并讨论了这一进程的框架。这导致确定了五个主题，即“定义和术语”、“研究方法”、“报告和结果”、“坚持锻炼”和“行动机制”。” 根据确定的主题，已经成立了五个专家组，他们将进一步 (a) 概述每个主题的挑战和 (b) 为向前推进提供建议。我们的目标是让 MS/MS 组织（例如多发性硬化症国际联合会 (MSIF) 和欧洲多发性硬化症平台 (EMSP)）的人员参与所有这五个主题并与之合作。生成具有多专家视角的主题框架可以提高 MS 运动研究的质量和范围，最终可能会改善 MS 患者的日常生活。多发性硬化症国际联合会 (MSIF) 和欧洲多发性硬化症平台 (EMSP)）在所有这五个主题中。生成具有多专家视角的主题框架可以提高 MS 运动研究的质量和范围，最终可能会改善 MS 患者的日常生活。多发性硬化症国际联合会 (MSIF) 和欧洲多发性硬化症平台 (EMSP)）在所有这五个主题中。生成具有多专家视角的主题框架可以提高 MS 运动研究的质量和范围，最终可能会改善 MS 患者的日常生活。