Objective To investigate potential causality between genetic liability to migraine and Alzheimer’s disease, intelligence,and brain volume using two-sample Mendelian randomization. Methods The exposure consisted of independent genetic variants associated with migraine in the largest (59,674 cases/316,078 controls) published genome-wide association study. Outcomes included Alzheimer’s disease (71,880 cases/383,378 controls), a measure of general intelligence (n = 269,867), intracranial volume (n = 11,373), and seven subcortical brain volumes (n ~ 13,000), all with available genome-wide association study summary statistics. Mendelian randomization effects were estimated using inverse-variance weighted analysis. Results Genetic liability to migraine did not associate with Alzheimer’s disease (odds ratio [95% confidence interval]1.01 [1.00–1.02], p = 0.07), intelligence (standardized beta [95% confidence interval] 0.01 [0.00–0.02], p = 0.13), or any brain volume measures (all p > 0.05). No individual migraine variant associated with any of the outcomes at genome-wide significance. Conclusions These data do not support a causal effect of migraine liability on Alzheimer’s disease, intelligence, or brainvolume.

中文翻译：

---

偏头痛的遗传倾向对认知和脑容量的影响：孟德尔随机化研究。

目的使用两样本孟德尔随机化研究偏头痛的遗传易感性与阿尔茨海默病、智力和脑容量之间的潜在因果关系。方法 在最大的（59,674 个病例/316,078 个对照）发表的全基因组关联研究中，暴露包括与偏头痛相关的独立遗传变异。结果包括阿尔茨海默病（71,880 例/383,378 名对照）、一般智力的测量（n = 269,867）、颅内体积（n = 11,373）和七个皮质下脑体积（n ~ 13,000），所有这些都具有可用的全基因组关联研究汇总统计。使用逆方差加权分析估计孟德尔随机化效应。结果 偏头痛的遗传倾向与阿尔茨海默病无关（优势比 [95% 置信区间]1.01 [1.00–1.02]，p = 0.07）、智力（标准化 beta [95% 置信区间] 0.01 [0.00–0.02]，p = 0.13）或任何脑容量测量值（所有 p > 0.05）。没有单个偏头痛变异与全基因组显着性的任何结果相关。结论 这些数据不支持偏头痛对阿尔茨海默病、智力或脑容量的因果影响。