Online informatics resources to facilitate cancer target and chemical probe discovery,RSC Medicinal Chemistry

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Online informatics resources to facilitate cancer target and chemical probe discovery
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2020-04-09 , DOI: 10.1039/d0md00012d
Xuan Yang _{1,

2} , Haian Fu _{1,

2,

3,

4} , Andrey A Ivanov _{1,

2,

3}

Affiliation

The advances in cancer genomics, chemical biology, high-throughput screening technologies, and synthetic medicinal chemistry have tremendously expanded the biological space of cancer targets and chemical space of bioactive small molecules to interrogate oncogenic signaling. To explore and leverage these exponentially growing cancer-associated data, a great number of computational tools, databases, and algorithms have been developed. This review summarizes recent cancer-related web resources that allow researchers working at the interface of chemical, biological, and cancer genomics fields to integrate clinical and genomics data for specific actionable targets and selective chemical compounds to facilitate cancer therapeutic discovery.

中文翻译：

促进癌症靶点和化学探针发现的在线信息学资源

癌症基因组学、化学生物学、高通量筛选技术和合成药物化学的进步极大地扩展了癌症靶标的生物学空间和生物活性小分子的化学空间，以探究致癌信号传导。为了探索和利用这些呈指数增长的癌症相关数据，人们开发了大量计算工具、数据库和算法。这篇综述总结了最近与癌症相关的网络资源，这些资源使化学、生物和癌症基因组学领域的研究人员能够整合特定可操作靶点和选择性化合物的临床和基因组学数据，以促进癌症治疗的发现。

更新日期：2020-04-09

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