Immune signatures measured at baseline and immediately prior to vaccination may predict the immune response to vaccination. Such pre-vaccine assessment might allow not only population-based, but also more personalized vaccination strategies ('precision vaccination'). If baseline immune signatures are predictive, the underlying mechanism they reflect may also determine vaccination outcome. Thus, baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses. This concept has the potential to transform vaccination strategies and usher in a new approach to improve global health.

中文翻译：

---

提高疫苗诱导的免疫力：基线可以预测结果吗？

在基线和紧接疫苗接种之前测量的免疫特征可以预测对疫苗接种的免疫反应。这种疫苗接种前评估可能不仅允许基于人群的疫苗接种，而且还允许更个性化的疫苗接种策略（“精确疫苗接种”）。如果基线免疫特征是可预测的，则它们反映的潜在机制也可能决定疫苗接种的结果。因此，基线特征可能有助于识别在疫苗接种之前要进行调节的干预目标，以改善疫苗接种反应。这个概念有可能改变疫苗接种策略，并提出一种改善全球健康的新方法。