Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis.,Cell Chemical Biology

当前位置： X-MOL 学术 › Cell Chem. Bio. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis.
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2020-04-09 , DOI: 10.1016/j.chembiol.2020.03.011
Annadurai Anandhan ₁ , Matthew Dodson ₁ , Cody J Schmidlin ₁ , Pengfei Liu ₁ , Donna D Zhang ₂

Affiliation

Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated in different disease contexts is uncovered, our understanding of the physiological and pathological relevance of this mode of cell death continues to grow. Along these lines, a host of pharmacological modulators of this pathway have been identified, targeting proteins involved in iron homeostasis; the generation and reduction of lipid peroxides; or cystine import and glutathione metabolism. Also, of note, many components of the ferroptosis cascade are target genes of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), indicating its critical role in mediating the ferroptotic response. In this review, we discuss the in vitro, in vivo, and clinical evidence of ferroptosis in disease, including a brief discussion of targeting upstream mediators of this cascade, including NRF2, to treat ferroptosis-driven diseases.

中文翻译：

铁甲防御系统的崩溃：NRF2 在介导铁死亡中的关键作用。

铁死亡是一种受调节的细胞死亡的非凋亡模式，依赖于铁和脂质过氧化。随着对铁死亡效应子及其在不同疾病背景下如何调节的新机制的了解，我们对这种细胞死亡模式的生理和病理相关性的理解不断加深。沿着这些思路，已经鉴定出该途径的许多药理学调节剂，其目标是参与铁稳态的蛋白质。脂质过氧化物的产生和减少；或胱氨酸输入和谷胱甘肽代谢。此外，值得注意的是，铁死亡级联的许多组成部分是转录因子核因子红细胞 2 相关因子 2 (NRF2) 的靶基因，表明其在介导铁死亡反应中发挥关键作用。在这篇综述中，我们讨论了疾病中铁死亡的体外、体内和临床证据，包括简要讨论了针对该级联的上游介质（包括 NRF2）来治疗铁死亡驱动的疾病。

更新日期：2020-04-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11