Accelerated emergence of drug- resistant pathogenic microbes, their unbeatable virulence and a gradual loss of efficacy of currently used antimicrobial agents over the last decade, have expanded the scope of herbal medicine to combat this emerging challenge to have a wide spectrum of activity to develop effective medicines with lesser untoward side effects. Plant-based natural products should be of utmost interest to today's pharmaceutical industries since they are a primary source of new chemical entities directed at new drug targets. Apocynaceae or ‘Dogbane’ family has attained a global reputation as a source of some life-saving plant-derived products and novel compounds. Members of this family have also been extensively investigated against several nosocomial pathogenic microbes through in vitro and in vivo experimental settings. Several plant-derived components obtained from members of this family have also exhibited remarkable microbial growth inhibitory properties. Popular and widely accepted international databases such as PubMed, Science Direct, ResearchGate, Scopus, Google Scholar, JSTOR and more were searched using the various search strings such as Apocynaceae, antimicrobials, multidrug resistance, resistance modifying agents and pathogenic microorganisms were used in various combinations to retrieve several citations related to the topic. The current review encompasses recent developments in experimental studies and phytochemical analyses which correlates with antimicrobial efficacy of selected Apocynaceous plants along with synergistic mechanism and structural details. The present review recognizes and leverages the importance of Apocynaceae plants, which could be of significant interest in the development of more effective and less toxic antimicrobial drugs which may surmount multidrug resistance. Three different paradigm models harnessing clinical antimicrobial resistance (AMR) including the plant family Apocynaceae, Gram-positive and Gram-negative bacterial species have been broadly discussed in this review. In a nutshell, the present review represents a comprehensive account on the antimicrobials and resistance modifying agents obtained from the members of the plant family Apocynaceae and derived phytochemicals. It also gives an insight into the underlying mode of action of these phytochemicals against an array of pathogenic bacteria, their mechanism of antibiosis, plant parts from which the phytochemicals were isolated or the extracts was prepared with a critical discussion on the botanically-derived antibiotics as a template for antimicrobial drug development.

在过去的十年中，耐药病原性微生物的出现，其无与伦比的毒力以及当前使用的抗菌剂的功效逐渐丧失，已经扩大了草药的范围，以应对这一新兴挑战，使其具有广泛的活动来开发有效的抗微生物剂。副作用较小的药物。基于植物的天然产物应该是当今制药行业最感兴趣的，因为它们是针对新药物目标的新化学实体的主要来源。夹竹桃科或“ Dogbane”家族作为一些救生植物衍生产品和新型化合物的来源而享誉全球。该家族的成员还通过体外和体外针对几种医院病原微生物进行了广泛研究。体内实验设置。从该家族成员中获得的几种植物来源的成分也表现出了显着的微生物生长抑制特性。使用各种搜索字符串（如夹竹桃科），抗菌素，多药耐药性，耐药修饰剂和病原微生物，以各种组合方式搜索了流行和广泛接受的国际数据库，例如PubMed，Science Direct，ResearchGate，Scopus，Google Scholar，JSTOR等。检索与该主题相关的一些引用。本篇综述涵盖了实验研究和植物化学分析的最新进展，这些进展与所选夹竹桃植物的抗菌功效以及协同机制和结构细节相关。本综述认识到并利用了夹竹桃植物的重要性，这对于开发可以克服多药耐药性的更有效和毒性更低的抗菌药物可能具有重大意义。在本文中，广泛讨论了三种利用临床抗菌素耐药性（AMR）的典范模型，其中包括植物夹竹桃科，革兰氏阳性和革兰氏阴性细菌。简而言之，本综述代表了对从植物夹竹桃科成员和衍生的植物化学药品中获得的抗微生物剂和抗性改良剂的全面介绍。还可以深入了解这些植物化学物质对一系列致病细菌的潜在作用方式，其抗菌作用机理，