We read with great interest the article by Wijnant et al. [1] in a recent issue of European Respiratory Journal investigating the longitudinal outcomes of patients with preserved ratio impaired spirometry (PRISm) in the Rotterdam cohort. PRISm is a subject of increased investigation as it is associated with respiratory symptoms, cardiovascular disease, metabolic syndrome and, quite clearly in the recent study, increased mortality [1–3]. While there have been numerous studies examining outcomes related to PRISm in high-income countries (HICs), few studies have assessed the clinical significance of this spirometric finding in low- and middle-income countries (LMICs). Does the high rate and unique risk factors of preserved ratio impaired spirometry in low- and middle-income countries have something to teach us about the physiology of this highly prevalent pattern? http://bit.ly/2SsQjeG

中文翻译：

---

PRISm 的全球意义：低收入和中等收入国家的数据如何将生理学与炎症联系起来

我们怀着极大的兴趣阅读了 Wijnant 等人的文章。[1] 在最近一期的《欧洲呼吸杂志》中，研究了鹿特丹队列中保留比率受损肺量计 (PRISm) 患者的纵向结果。PRISm 是一个越来越多的研究对象，因为它与呼吸系统症状、心血管疾病、代谢综合征有关，并且在最近的研究中非常清楚地表明它会增加死亡率 [1–3]。虽然有许多研究检查了高收入国家 (HIC) 中与 PRISm 相关的结果，但很少有研究评估了这一肺活量测定结果在低收入和中等收入国家 (LMIC) 中的临床意义。在低收入和中等收入国家，保持比率受损的肺活量测定的高发生率和独特风险因素是否可以让我们了解这种高度普遍模式的生理学？http://bit.ly/2SsQjeG