In a recent paper published in the European Respiratory Journal, we studied the characteristics, trajectory and mortality of subjects with Preserved Ratio Impaired Spirometry (PRISm) in the Rotterdam Study, a prospective population-based cohort study in the Netherlands, a high-income country (HIC) [1]. In an elegant letter to the editor, P. Jackson and T. Siddharthan correctly argue that clinical research on PRISm has been limited so far in its potential to grasp a representative sample of the world population, with marked underrepresentation of studies in low- and middle-income countries (LMICs). Despite potential differences in risk factors, they suggest that systemic inflammation plays a key role in the pathogenesis of PRISm in both HIC and LMICs. Subjects with PRISm represent a heterogeneous population encompassing distinct phenotypes with distinct risk factors. A spectrum of mechanisms and risk factors contribute to varying degrees to the pathogenesis of PRISm in different populations. http://bit.ly/2TkHJjK

中文翻译：

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PRISm 的全球意义：来自低收入和中等收入国家的数据如何将生理学与炎症联系起来

在最近发表在欧洲呼吸杂志上的一篇论文中，我们研究了鹿特丹研究中保留比率受损肺活量测定 (PRISm) 受试者的特征、轨迹和死亡率，鹿特丹研究是在高收入国家荷兰进行的一项基于人群的前瞻性队列研究(HIC) [1]。在给编辑的一封优雅的信中，P. Jackson 和 T. Siddharthan 正确地指出，迄今为止，关于 PRISm 的临床研究在掌握世界人口代表性样本方面的潜力有限，中低端研究的代表性明显不足。 - 收入国家（LMIC）。尽管风险因素存在潜在差异，但他们认为全身炎症在 HIC 和 LMIC 的 PRISm 发病机制中起着关键作用。患有 PRISm 的受试者代表包含具有不同风险因素的不同表型的异质人群。一系列机制和风险因素在不同人群中对 PRISm 的发病机制有不同程度的影响。http://bit.ly/2TkHJjK