Cu(II)-Metallacryptands Self-Assembled to Vesicular Aggregates Capable of Encapsulating and Transporting an Anticancer Drug Inside Cancer Cells.,Macromolecular Bioscience

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Cu(II)-Metallacryptands Self-Assembled to Vesicular Aggregates Capable of Encapsulating and Transporting an Anticancer Drug Inside Cancer Cells.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-04-08 , DOI: 10.1002/mabi.202000044
Protap Biswas ₁ , Koushik Sarkar ₁ , Parthasarathi Dastidar ₁

Affiliation

Crystallographically characterized M₂L₄ type cationic Cu(II)‐metallacryptands [MC(X)] derived from a series of bis‐pyridyl‐bis‐urea ligands (L_X; X = O, S, C) are self‐assembled to single‐layered vesicular aggregates in DMSO, DMSO/water, and DMSO/DMEM (biological media). One such vesicle is MC(O)‐vesicle that is demonstrated to be able to load and release (pH responsive) an anticancer drug, namely doxorubicin hydrochloride (DOX). DOX‐loaded MC(O)‐vesicle is also successfully transported within MDA‐MB‐231 cells—a highly aggressive human breast cancer cell line. Such self‐assembling behavior to form vesicular aggregates by metallacryptands (MCs) is hitherto unknown.

中文翻译：

铜（II）-金属隐窝分子自组装成能够在癌细胞内封装和运输抗癌药物的水泡聚集体。

由一系列双吡啶基双脲配体（L _X； X = O，S，C）衍生的晶体学表征的M ₂ L ₄型阳离子型Cu（II）-金属隐链晶[MC（X）] DMSO，DMSO /水和DMSO / DMEM（生物介质）中的单层囊状聚集体。一种这样的囊泡是MC（O）囊泡，它被证明能够负载和释放（pH响应）抗癌药物，即盐酸阿霉素（DOX）。载有DOX的MC（O）囊泡还可以在MDA-MB-231细胞（一种高度侵袭性的人类乳腺癌细胞系）中成功运输。迄今为止，这种自组装行为由金属隐链藻（MC）形成水泡聚集体的现象尚不为人所知。

更新日期：2020-04-08

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