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Enhancement of the apoptotic effects of Arctii Fructus extracts on cancer cells by the enzymatic bioconversion of lignans.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-04-08 , DOI: 10.1002/fsn3.1336 Jung-Eun Kim 1 , Nam Hyouck Lee 1 , Young Ho Kim 1 , Young Eon Kim 2 , Tae-Gyu Lim 3 , Kyung-Mo Song 1
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-04-08 , DOI: 10.1002/fsn3.1336 Jung-Eun Kim 1 , Nam Hyouck Lee 1 , Young Ho Kim 1 , Young Eon Kim 2 , Tae-Gyu Lim 3 , Kyung-Mo Song 1
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The fruit of Arctium lappa L. (Arctii Fructus) is one of the most popularly used medicinal plant components in Asia. To enhance the functionality of Arctii Fructus extract, a bioconversion method was developed to produce arctigenin from arctiin. Treatment with β‐glucosidase increased the arctigenin content by >5 fold in Arctii Fructus extracts. The bioconversion products enhanced the apoptosis of cancer cells. The cell viabilities of gefitinib‐resistant lung cancer HCC827 (HCC827GR) cells and colon cancer cells (DLD1) were decreased by 40% and 35%, respectively. The bioconversion products also decreased anchorage‐independent growth of cancer cells. In addition, the increase of apoptosis in cancer cells by bioconversion was confirmed by the flow cytometry analysis. These results indicated that arctigenin exerts anticancer effects on lung and colon cancer cells and that Arctii Fructus can potentially function as a chemopreventive agent. In addition, bioconverted Arctii Fructus extract displayed higher anticancer activity than the same levels of purified arctigenin, indicating the advantage of consuming Arctii Fructus itself as a food or medicinal material.
中文翻译：
通过木酚素的酶促生物转化增强牛蒡子提取物对癌细胞的凋亡作用。
Arctium lappa L. (Arctii Fructus) 的果实是亚洲最常用的药用植物成分之一。为了增强牛蒡子提取物的功能，开发了一种生物转化方法从牛蒡子苷生产牛蒡子苷元。用 β-葡萄糖苷酶处理后，牛蒡子提取物中的牛蒡甙元含量增加了 5 倍以上。生物转化产品增强了癌细胞的凋亡。吉非替尼耐药的肺癌 HCC827 (HCC827GR) 细胞和结肠癌细胞 (DLD1) 的细胞活力分别降低了 40% 和 35%。生物转化产品还减少了癌细胞的非贴壁依赖性生长。此外，通过流式细胞术分析证实了生物转化引起的癌细胞凋亡的增加。这些结果表明牛蒡甙元对肺癌和结肠癌细胞具有抗癌作用，并且牛蒡子可以作为化学预防剂。此外，生物转化的牛蒡子提取物比相同水平的纯化牛蒡子苷元显示出更高的抗癌活性，表明将牛蒡子本身作为食品或药用材料食用的优势。
更新日期：2020-04-08
中文翻译：
通过木酚素的酶促生物转化增强牛蒡子提取物对癌细胞的凋亡作用。
Arctium lappa L. (Arctii Fructus) 的果实是亚洲最常用的药用植物成分之一。为了增强牛蒡子提取物的功能，开发了一种生物转化方法从牛蒡子苷生产牛蒡子苷元。用 β-葡萄糖苷酶处理后，牛蒡子提取物中的牛蒡甙元含量增加了 5 倍以上。生物转化产品增强了癌细胞的凋亡。吉非替尼耐药的肺癌 HCC827 (HCC827GR) 细胞和结肠癌细胞 (DLD1) 的细胞活力分别降低了 40% 和 35%。生物转化产品还减少了癌细胞的非贴壁依赖性生长。此外，通过流式细胞术分析证实了生物转化引起的癌细胞凋亡的增加。这些结果表明牛蒡甙元对肺癌和结肠癌细胞具有抗癌作用，并且牛蒡子可以作为化学预防剂。此外，生物转化的牛蒡子提取物比相同水平的纯化牛蒡子苷元显示出更高的抗癌活性，表明将牛蒡子本身作为食品或药用材料食用的优势。
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