Effect of Crystallization Conditions on the Metastable Zone Width and Nucleation Kinetics of p‐Aminobenzoic Acid in Ethanol,Chemical Engineering & Technology

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Effect of Crystallization Conditions on the Metastable Zone Width and Nucleation Kinetics of p‐Aminobenzoic Acid in Ethanol
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-05-07 , DOI: 10.1002/ceat.201900679
Siti Zulaikha Mohd Noor ₁ , Diana M. Camacho ₁ , Cai Yun Ma ₁ , Tariq Mahmud ₁

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A detailed knowledge of the metastable zone width (MSZW) and nucleation kinetics is vital for the design of batch cooling crystallization processes. Factors such as cooling rate and impeller speed affect the MSZW and nucleation kinetics. Crystallization and dissolution temperatures were measured as a function of cooling rate and impeller speed during the batch cooling crystallization of p‐aminobenzoic acid (pABA) from ethanol in a 0.5‐L stirred‐tank crystallizer. The polythermal experimental data were analyzed using the Nyvlt and first principles‐based Kashchiev‐Borissova‐Hammond‐Roberts (KBHR) methods. In all experimental cases, the latter model revealed that the nucleation process of pABA in ethanol was dominated by an instantaneous nucleation mechanism. The Nyvlt and KBHR analyses delivered a range of parameter values associated with a power‐law model describing the nucleation rate as well as the concentration of nuclei.

中文翻译：

结晶条件对乙醇中对氨基苯甲酸亚稳区宽度和成核动力学的影响

对亚稳态区宽度（MSZW）和成核动力学的详细了解对于分批冷却结晶过程的设计至关重要。冷却速度和叶轮速度等因素会影响MSZW和成核动力学。在p的分批冷却结晶过程中，根据冷却速率和叶轮速度测量结晶和溶解温度。在0.5升搅拌釜结晶器中从乙醇中提取氨基苯甲酸（pABA）。使用Nyvlt和基于第一原理的Kashchiev-Borissova-Hammond-Roberts（KBHR）方法分析了多热实验数据。在所有实验情况下，后一种模型都表明乙醇中pABA的成核过程由瞬时成核机制决定。Nyvlt和KBHR分析提供了与幂律模型相关的一系列参数值，这些幂值模型描述了成核速率以及原子核浓度。

更新日期：2020-05-07

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