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A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice.
Food & Function ( IF 5.1 ) Pub Date : 2020-04-08 , DOI: 10.1039/d0fo00206b Ana Lemus-Conejo 1 , Elena Grao-Cruces 2 , Rocio Toscano 1 , Lourdes M Varela 3 , Carmen Claro 4 , Justo Pedroche 5 , Francisco Millan 5 , Maria C Millan-Linares 6 , Sergio Montserrat-de la Paz 2
Food & Function ( IF 5.1 ) Pub Date : 2020-04-08 , DOI: 10.1039/d0fo00206b Ana Lemus-Conejo 1 , Elena Grao-Cruces 2 , Rocio Toscano 1 , Lourdes M Varela 3 , Carmen Claro 4 , Justo Pedroche 5 , Francisco Millan 5 , Maria C Millan-Linares 6 , Sergio Montserrat-de la Paz 2
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Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg-1 day-1 or 1 mg kg-1 day-1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways.
中文翻译：
羽扇豆（Lupinus angustifolious L.）肽可预防高脂饮食诱导的肥胖小鼠的非酒精性脂肪肝疾病。
生物活性肽与许多疾病的预防和治疗有关。GPETAFLR是一种八肽，已从羽扇豆（Lupinus angustifolius L.）中分离出来，具有抗炎特性。这项研究的目的是评估GPETAFLR预防高脂饮食（HFD）诱导的肥胖小鼠中非酒精性脂肪肝疾病（NAFLD）的潜在活性。给C57BL / 6J小鼠喂食标准饮食或HFD。饲喂HFD饮食的两组中的GPETAFLR在饮用水中以0.5 mg kg-1 day-1或1 mg kg-1 day-1进行了处理。为了确定GPETAFLR改善非酒精性脂肪肝发病和进展的能力，分析了组织学研究，肝酶谱，炎性细胞因子和脂质代谢相关基因和蛋白质。我们的结果表明，用GPETAFLR治疗可以缓解HFD引起的炎症代谢紊乱。总之，饮食中的羽扇豆食用可能可以通过改变肝脏的脂质信号通路来修复HFD所致的肝损害。
更新日期：2020-04-08
中文翻译：
羽扇豆（Lupinus angustifolious L.）肽可预防高脂饮食诱导的肥胖小鼠的非酒精性脂肪肝疾病。
生物活性肽与许多疾病的预防和治疗有关。GPETAFLR是一种八肽，已从羽扇豆（Lupinus angustifolius L.）中分离出来，具有抗炎特性。这项研究的目的是评估GPETAFLR预防高脂饮食（HFD）诱导的肥胖小鼠中非酒精性脂肪肝疾病（NAFLD）的潜在活性。给C57BL / 6J小鼠喂食标准饮食或HFD。饲喂HFD饮食的两组中的GPETAFLR在饮用水中以0.5 mg kg-1 day-1或1 mg kg-1 day-1进行了处理。为了确定GPETAFLR改善非酒精性脂肪肝发病和进展的能力，分析了组织学研究，肝酶谱，炎性细胞因子和脂质代谢相关基因和蛋白质。我们的结果表明，用GPETAFLR治疗可以缓解HFD引起的炎症代谢紊乱。总之，饮食中的羽扇豆食用可能可以通过改变肝脏的脂质信号通路来修复HFD所致的肝损害。
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