One of the major limitations of current cancer therapy is the inability to destroy tumors with high efficacy and minimal invasiveness. Herein, we developed a proof-of-concept fixed-point "blasting" strategy to destroy the "castle" of tumors and realized efficient interventional photothermal therapy. The "blasting" materials were composed of photothermal nanoparticles (ancient ink nanoparticles, AINP) and a low boiling point phase change agent (perfluoromethylcyclopentane, FMCP). An injectable in situ-forming thermal-responsive hydrogel composed of biodegradable and biocompatible polymers was employed as a carrier to load the AINP and FMCP. The obtained hydrogel system was a flowable aqueous solution at low or room temperature for facile injection; meanwhile, once administered, it rapidly transformed into a fixed gel at a body temperature of about 37 °C. This unique property could effectually fix the AINP and FMCP and thus restrict the destruction region inside the tumor. Subsequently, triggered by second window near-infrared light, the solid tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage. We envisage that this fixed-point "blasting" strategy will pave a new way for the next generation of cancer-interventional photothermal therapy.

中文翻译：

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由第二个近红外窗口光触发的定点“爆炸”，用于增强介入光热疗法。

当前癌症治疗的主要限制之一是不能以高效的功效和最小的侵袭性破坏肿瘤。在这里，我们开发了一种概念验证的定点“爆破”策略，以摧毁肿瘤的“城堡”，并实现了有效的介入光热疗法。“喷射”材料由光热纳米粒子（古老的墨水纳米粒子，AINP）和低沸点相变剂（全氟甲基环戊烷，FMCP）组成。由可生物降解和生物相容性聚合物组成的可注射原位形成的热响应水凝胶被用作载体来加载AINP和FMCP。所获得的水凝胶体系是在低温或室温下易于注射的可流动的水溶液。同时，一旦给药，它在约37°C的体温下迅速转变为固定的凝胶。这种独特的性质可以有效地固定AINP和FMCP，从而限制了肿瘤内部的破坏区域。随后，由第二窗近红外光触发，通过温和的光热效应和随后的气体机械损伤有效地破坏了实体瘤。我们设想，这种定点“爆炸”策略将为下一代癌症介入光热疗法铺平一条新途径。轻度的光热作用和随后的气体机械损伤有效地破坏了实体瘤。我们设想，这种定点“爆炸”策略将为下一代癌症介入光热疗法铺平一条新途径。轻度的光热作用和随后的气体机械损伤有效地破坏了实体瘤。我们设想，这种定点“爆炸”策略将为下一代癌症介入光热疗法铺平一条新途径。