Mindfulness-based interventions have shown some efficacy in decreasing stress levels and improving quality of life. However, so far, only a few studies have studied this type of intervention among patients with inflammatory bowel disease and none of them have studied their effects on inflammatory biomarkers. This current study was a two-armed, single-centre, randomised (2:1 ratio) controlled trial used to evaluate the effects of a mindfulness-based intervention (n = 37) compared to standard medical therapy (n = 20) in patients with Crohn’s disease or ulcerative colitis. The mindfulness intervention blended four internet-based therapy modules with four face-to-face support sessions. The outcomes we assessed were faecal calprotectin (primary outcome), C-reactive protein, and cortisol levels measured in hair samples at several timepoints. The between-group analysis highlighted significant decreases in faecal calprotectin and in C-reactive protein levels in the mindfulness-based intervention group compared to the standard medical therapy group at the six-month follow-up (faecal calprotectin: −367, [95% CI: −705, −29], P = 0.03; C-reactive protein: −2.82, [95% CI: −5.70, 0.08], P = 0.05), with moderate to large effect sizes (faecal calprotectin: ηp² = 0.085; C-reactive protein: ηp² = 0.066). We concluded that mindfulness-based therapy administered as part of standard clinical practice effectively improves inflammatory biomarkers in patients diagnosed with inflammatory bowel disease.

基于正念的干预措施已显示出在降低压力水平和改善生活质量方面的某些功效。然而，到目前为止，只有少数研究对炎症性肠病患者进行了此类干预研究，而没有研究对炎症性生物标志物的影响。本研究是一项两臂，单中心，随机（比率为2：1）的对照试验，用于评估基于正念的干预（n  = 37）与标准药物治疗（n = 20）克罗恩氏病或溃疡性结肠炎患者。正念干预将四个基于互联网的治疗模块与四个面对面的支持会议相结合。我们评估的结果是在几个时间点测量的头发样本中的粪便钙卫蛋白（主要结果），C反应蛋白和皮质醇水平。组间分析显示，在六个月的随访中，与标准药物治疗组相比，基于正念的干预组的粪便钙卫蛋白和C反应蛋白水平显着降低（粪钙卫蛋白：−367，[95％ CI：-705，-29]，P  = 0.03; C反应蛋白：-2.82，[95％CI：-5.70，0.08]，P  = 0.05），具有中等至较大的效果大小（粪便钙卫蛋白：ηP ² = 0.085; C-反应蛋白：ηP ²  = 0.066）。我们得出的结论是，作为标准临床实践的一部分进行的基于正念疗法的治疗可有效改善诊断为炎症性肠病的患者的炎症生物标志物。