Infants and young children commonly consume apple-based products, which may contain high concentrations of inorganic arsenic (iAs). As yet, iAs exposure from ingesting apple products has not been well characterized in early childhood. Therefore, we investigated the association between urinary arsenic concentrations and intake of apple products in 1-year-old infants participating in the New Hampshire Birth Cohort Study. A 3-day food diary prior to collection of a spot urine sample was used to determine infant’s consumption of apple products. The sum of urinary iAs, monomethylarsonic acid, and dimethylarsinic acid, referred to as ΣAs, was used to estimate iAs exposure. A total of 242 infants had urinary arsenic speciation analyzed without indication of fish/seafood consumption (urinary arsenobetaine < 1 µg/L) and with a completed 3-day food diary. Of these, 183 (76%) infants ate apples or products containing apple. The geometric mean urinary ΣAs among the 59 infants who did not consume any type of apple product was 2.78 µg/L as compared to 2.38, 2.46, 2.28, and 2.73 µg/L among infants who exclusively consumed apple juice (n = 30), apple puree (n = 67), apples as whole fruit (n = 20), or products mixed with apples (n = 21), respectively. Differences in urinary ΣAs associated with apple consumption were not statistically significant in generalized linear models adjusted for urine dilution, rice consumption, and household water arsenic. Thus, while infants in our study frequently consumed apples and apple products, we did not find evidence that it increased iAs exposure.

婴幼儿通常食用以苹果为原料的产品，这些产品可能含有高浓度的无机砷 (iAs)。迄今为止，幼儿时期因摄入苹果产品而接触的 iAs 尚未得到很好的表征。因此，我们调查了参与新罕布什尔州出生队列研究的 1 岁婴儿尿砷浓度与苹果产品摄入量之间的关联。在收集点尿样本之前的三天食物日记被用来确定婴儿对苹果产品的消耗。尿液中 iAs、一甲基胂酸和二甲基胂酸的总和（称为 ΣAs）用于估计 iAs 暴露量。对总共 242 名婴儿进行了尿砷形态分析，未表明是否食用鱼类/海鲜（尿砷甜菜碱 < 1 µg/L），并填写了完整的 3 天食物日记。其中，183 名（76%）婴儿食用了苹果或含有苹果的产品。59 名未食用任何类型苹果产品的婴儿的几何平均尿 ΣAs 为 2.78 µg/L，而仅食用苹果汁的婴儿的几何平均尿 ΣAs 为 2.38、2.46、2.28 和 2.73 µg/L（n  = 30），分别是苹果泥 ( n  = 67)、苹果整个水果 ( n  = 20) 或与苹果混合的产品 ( n  = 21)。在根据尿液稀释、大米消耗和家庭用水砷进行调整的广义线性模型中，与苹果消耗相关的尿液ΣAs差异没有统计学意义。因此，虽然我们研究中的婴儿经常食用苹果和苹果产品，但我们没有发现证据表明它会增加 iAs 暴露。