The determination of boron in animal organ tissues using inductively coupled plasma atomic emission spectroscopy (ICP AES) has been optimized for analytical support of boron neutron capture therapy of cancerous tumors. The proposed technique is universal and rapid. The methodology includes: preliminary acid decomposition at elevated temperatures and pressure (if necessary), determination of boron by ICP AES in the obtained solutions using reference samples based on single-element solutions. The method is verified by spike experiment and varying the weight-samples. The ICP AES technique was used to evaluate the accumulation of boronophenylalanine and borocaptate in mice organs. Biodistribution of 10B in the case of intravenous administration of the drug to SCID mice with SPF status using the human glioblastoma cell line U87 was investigated.

中文翻译：

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用电感耦合等离子体原子发射光谱法测定硼。10B在荷瘤小鼠体内的生物分布

使用电感耦合等离子体原子发射光谱 (ICP AES) 测定动物器官组织中的硼已被优化，以支持癌性肿瘤的硼中子俘获疗法的分析支持。所提出的技术是通用且快速的。该方法包括：在升高的温度和压力下进行初步酸分解（如有必要），使用基于单元素溶液的参考样品通过 ICP AES 测定所得溶液中的硼。该方法通过尖峰实验和改变重量样本来验证。ICP AES 技术用于评估小鼠器官中硼苯丙氨酸和硼烷酸盐的积累。在使用人胶质母细胞瘤细胞系 U87 向具有 SPF 状态的 SCID 小鼠静脉内施用药物的情况下，研究了 10B 的生物分布。