Alginate hydrogel-coated syringe needles for rapid haemostasis of vessel and viscera puncture.,Biomaterials

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Alginate hydrogel-coated syringe needles for rapid haemostasis of vessel and viscera puncture.
Biomaterials ( IF 12.8 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.biomaterials.2020.120019
Jingli Ren ₁ , Xingjie Yin ₂ , Yu Chen ₂ , Yu Chen ₁ , Hua Su ₂ , Ke Wang ₁ , Lianbin Zhang ₁ , Jintao Zhu ₁ , Chun Zhang ₂

Affiliation

Tissue puncture is an effective means in the diagnosis and treatment of diseases, providing important information for clinical doctors. Yet, haemorrhage is still a main and unavoidable complication, which can cause serious outcomes, especially in patients with abnormal coagulation function. Herein, we present a facile yet effective strategy to prepare haemostatic needles by coating the syringe needles surface with alginate-CaCl2-based hydrogel with carefully optimized mechanical and chemical properties, which can effectively prevent bleeding following tissue puncture. The needle with haemostatic coating exhibits complete prevention of blood loss following vessel and viscera puncture in the normal animal as well as in animal models with hemorrhagic diathesis. The syringe needle with haemostatic coating in this work holds enormous potentials for clinical applications, including sampling and injection.

中文翻译：

藻酸盐水凝胶涂层注射器针头可快速止血血管和内脏穿刺。

组织穿刺是诊断和治疗疾病的有效手段，为临床医生提供重要信息。然而，出血仍然是主要且不可避免的并发症，可能导致严重的后果，尤其是在凝血功能异常的患者中。在本文中，我们提出了一种简便而有效的策略，即通过在注射器针头表面涂以经过精心优化的机械和化学性质的藻酸盐-CaCl2基水凝胶来制备止血针，可以有效防止组织穿刺后的出血。带有止血涂层的针头在正常动物以及具有出血性素质的动物模型中，可以完全防止血管和内脏穿刺后失血。

更新日期：2020-04-20

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