Behavioral evidence suggests that different mechanisms mediate duration perception depending on whether regular or irregular cues for time estimation are provided, and that individual differences in interoceptive processing may affect duration perception only in the latter case. However, no study has addressed brain correlates of this proposed distinction. Here participants performed a duration reproduction task in two conditions: with unevenly spaced stimuli during time estimation/reproduction (irregular), with regularly spaced stimuli provided during the same task (regular). They also underwent resting-state fMRI to assess regional functional connectivity, in order to link individual differences in behavioral performance to variations in patterns of intrinsic brain oscillations. Resting-state functional connectivity of the right precentral gyrus with the ipsilateral insula and putamen was predicted by duration reproduction performance selectively in the irregular condition. The connectivity of the right posterior insula, within a network modulated by participants' degree of interoceptive awareness, correlated positively with performance in the irregular condition only. Findings support the distinction between brain networks involved in duration processing with or without regular cues, and the hypothesis that the multimodal integration of interoceptive and exteroceptive cues is specifically involved in the latter.

中文翻译：

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静止状态功能连接性的个体差异与不规则情况下的间隔时间有关。

行为证据表明，取决于是否提供规则或不规则的时间估计线索，不同的机制介导了持续时间知觉，并且在感知过程中的个体差异可能仅在后一种情况下影响持续时间知觉。但是，尚无研究解决这种提议的大脑相关性。在此，参与者在两种情况下执行持续时间再现任务：在时间估计/再现过程中具有不均匀间隔的刺激（不规则），在相同任务中（规则）具有规则间隔的刺激。他们还进行了静息状态功能磁共振成像以评估区域功能的连通性，以便将行为表现的个体差异与内在的大脑振动模式的变化联系起来。右中前回与同侧岛状和壳状核的静止状态功能连接是通过在不规则状态下选择性地进行持续繁殖来预测的。右后岛的连通性在参与者感知觉程度的调节下的网络内，仅与不规则状态下的表现呈正相关。研究结果支持了在有或没有规则提示的持续时间处理中所涉及的大脑网络之间的区别，以及在后者中专门涉及了知觉和外知提示的多峰整合的假设。在网络中由参与者的感知觉意识程度调制，仅与不规则条件下的表现呈正相关。研究结果支持了在有或没有规则提示的持续时间处理中所涉及的大脑网络之间的区别，以及在后者中专门涉及了知觉和外知提示的多峰整合的假设。在网络中由参与者的感知觉意识程度调制，仅与不规则条件下的表现呈正相关。研究结果支持了在有或没有规则提示的持续时间处理中所涉及的大脑网络之间的区别，以及在后者中专门涉及了知觉和外知提示的多峰整合的假设。