In this issue of Cell Host & Microbe, Zhang et al. use a sepsis mouse model to show that macrophage-specific release of coagulation factor F3 depends on pathogen detection and responses mediated by TMEM173/STING. The therapeutic power of targeting TMEM173/STING-F3 is evident in mice, but will it penetrate the sepsis bedside?

中文翻译：

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摆脱脓毒症？

在本期《细胞宿主与微生物》中，Zhang等人。使用脓毒症小鼠模型来显示凝血因子F3的巨噬细胞特异性释放取决于病原体检测和TMEM173 / STING介导的反应。靶向TMEM173 / STING-F3的治疗能力在小鼠中很明显，但是会穿透败血症床边吗？