Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.

中文翻译：

---

HIV-1潜在水库的生物学及其对治疗策略的影响。

抗逆转录病毒疗法（ART）抑制HIV复制，但不能治愈。在ART期间，整合的HIV基因组在CD4 + T细胞甚至其他细胞中无限期存在。在这里，我们描述了被认为有助于其在治疗过程中持久性的机制，并着重介绍了许多最近的研究结果，这些研究描述了该过程中细胞增殖的重要性。阐明生物学的持续进展将增强我们开发有效的治疗性干预措施的能力。